Download PDF
Synlett 1997; 1997(SI): 467-468
DOI: 10.1055/s-1997-6141
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Asymmetric Hydrogenation of Cyclic α,β-Unsaturated Ketones to Chiral Allylic Alcohols

Takeshi Ohkuma, Hideyuki Ikehira, Takao Ikariya, Ryoji Noyori*
  • *ERATO Molecular Catalysis Project, Research Development Corporation of Japan, 1247 Yachigusa, Yakusa-cho, Toyota 470-03, Japan, FAX +81-52-783-4177; E-mail noyori@chem3.chem.nagoya-u.ac.jp
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The Ru(II)-BINAP-1,2-diphenylethylenediamine combined catalyst system effects asymmetric hydrogenation of certain cyclic enones in 2-propanol containing KOH with a substrate/catalyst molar ratio of 250 to 2500. The hydrogenation occurs selectively at the C=O function with excellent enantio- or diastereoselectivity.

asymmetric hydrogenation - BINAP - chiral allylic alcohol - chiral - 1,2-diamine - α,β-unsaturated ketone