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Synlett 1997; 1997(SI): 511-512
DOI: 10.1055/s-1997-6147
DOI: 10.1055/s-1997-6147
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Synthesis of a Novel Class of Water-Soluble and Bioavailable Antioxidants: 5-Hydroxycoumaran Derivatives Possessing Imidazole Group
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
The 5-hydroxycoumaran derivative 1 possessing imidazole group was synthesized from 2-isopropyl-6-methylphenol with high regioselectivity. The compound 1 was the water-soluble antioxidant with potent bioavailability and showed TXA2 synthase inhibition.
5-hydroxycoumaran - formylation - antioxidant - radical scavenger - thromboxane A2 synthase inhibitor