Synlett 1997; 1997(1): 54-56
DOI: 10.1055/s-1997-690
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Palladium-Catalysed Vinylic Substitution of Dimethyl Esters of N-Alkoxycarbonylkainic Acids with Aryl Halides

Sandro Cacchi1 , Giancarlo Fabrizi2 , Carlo Gallina3 , Paola Pace2
  • 1Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy, Fax +39 (6)4991.2780; e-mail: cacchi@axrma.uniroma1.it
  • 2Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy
  • 3Istituto di Scienze Farmaceutiche, Università “G. D’Annunzio”, Via Vicoli 19, 66100 Chieti, Italy
Further Information

Publication History

Publication Date:
22 March 2004 (online)

The palladium-catalysed reaction of dimethyl esters of N-alkoxycarbonylkainic acids with aryl halides in the presence of catalytic amounts of Pd(OAc)2 and of the n-Bu4NCl/NaHCO3 combination affords stereoselectively the corresponding E vinylic substitution products in satisfactory yield.