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Synlett 1997; 1997(1): 54-56
DOI: 10.1055/s-1997-690
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Palladium-Catalysed Vinylic Substitution of Dimethyl Esters of N-Alkoxycarbonylkainic Acids with Aryl Halides

Sandro Cacchi1 , Giancarlo Fabrizi2 , Carlo Gallina3 , Paola Pace2
  • 1Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy, Fax +39 (6)4991.2780; e-mail: cacchi@axrma.uniroma1.it
  • 2Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università “La Sapienza”, P.le A. Moro 5, 00185 Roma, Italy
  • 3Istituto di Scienze Farmaceutiche, Università “G. D’Annunzio”, Via Vicoli 19, 66100 Chieti, Italy
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Publication History

Publication Date:
22 March 2004 (online)

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The palladium-catalysed reaction of dimethyl esters of N-alkoxycarbonylkainic acids with aryl halides in the presence of catalytic amounts of Pd(OAc)2 and of the n-Bu4NCl/NaHCO3 combination affords stereoselectively the corresponding E vinylic substitution products in satisfactory yield.

kainic acid - palladium catalysis - vinylic substitution - aryl halides