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Synlett 1997; 1997(2): 223-224
DOI: 10.1055/s-1997-728
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Condensation of Dimethyl-3-methylglutaconate with Aminoaldehydes: A Diastereoselective Synthesis of 5,6-Dihydro-(2H)-pyran-2-ones

Nathalie Piveteau, Patrick Audin* , Laurent Ettouati, Joëlle Paris
  • *Laboratoire de Chimie Thérapeutique, ISPB, Faculté de Pharmacie, 8 Avenue Rockefeller 69373 LYON Cedex 08, Fax: (33) 04 78 77 71 58; Email: audin@univ-lyon.fr
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Publication History

Publication Date:
31 December 2000 (online)

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Dimethyl-3-methylglutaconate reacts with chiral α-aminoaldehydes under basic conditions to afford substituted 5,6-dihydro-(2H)-pyran-2-ones. The anti derivatives were obtained in a diastereoselective manner.

aldolisation - aminoaldehydes - dimethyl-3-methylglutaconate - 5,6-dihydro-(2H)-pyran-2-ones - diastereoselectivity