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Synlett 1997; 1997(3): 253-254
DOI: 10.1055/s-1997-786
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Asymmetric Syntheses of Both Enantiomers of α-Benzylserine and α-Carboxymethylserine

Manabu Horikawa1 , Terumi Nakajima, Yasufumi Ohfune2
  • 1Suntory Institute for Bioorganic Research, Shimamoto-cho, Mishima-gun, Osaka 618, Japan, Fax: 81-75-962-2115; E-mail: LEE05541@niftyserve.or.jp
  • 2Department of Material Science, Faculty of Science, Osaka City University, Sugimoto, Sumiyoshi, Osaka 558, Japan, Fax: 81-6-605-3153
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Publication History

Publication Date:
31 December 2000 (online)

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Both enantiomers of α-benzyl and α-carboxymethyl serines (1, 2) were efficiently synthesized starting with the known phenyl acetol via an intramolecular asymmetric Strecker synthesis.

intramolecular asymmetric Strecker synthesis - α-benzylserine - α-carboxymethylserine - α,α-disubstituted α-amino acid