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Synlett 1997; 1997(4): 384-386
DOI: 10.1055/s-1997-794
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A Palladium Catalyzed Synthesis of Precursors of 2-Amino-5-Phosphonopentanoic Acid and Related Compounds

Mireille Attolini, Michel Maffei1 , Bruno Principato, Gilbert Pfeiffer2
  • 1Laboratoire des Organo-Phosphorés, URA 1409 du C.N.R.S., B.P. 552, Faculté de Seint Jérôme, Avenue Escadrille Normandie Niémen, 13397 Marseille Cedex 20, France, Fax: (33) 3 91 28 80 30, E-mail: Michel.Maffei@LOP.u-3mrs.fr
  • 2Laboratoire des Organo-Phosphorés, URA 1409 du C.N.R.S., B.P. 552, Faculté de Seint Jérôme, Avenue Escadrille Normandie Niémen, 13397 Marseille Cedex 20, France, Fax: (33) 3 91 28 80 30
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Publication History

Publication Date:
31 December 2000 (online)

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The palladium(0)-catalyzed reaction of 3-acetoxy 1-alkenyl phosphonates 3 with ethyl (diphenyl methylene amino acetate) 4 and N,O bis(trimethylsilyl) acetamide provides the precursors of the title compounds in high yields.

3-acetoxy-1-vinyl phosphonates - amino acids - 2-amino-5-phosphonovaleric acid - ethyl (diphenylmethylene amino acetate) - palladium-catalyzed allylic substitution