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Synlett 1997; 1997(Sup. I): 485-487
DOI: 10.1055/s-1997-940277
DOI: 10.1055/s-1997-940277
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Glucopyranose Spirohydantoins: Specific Inhibitors of Glycogen Phosphorylase
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Publication History
Publication Date:
12 April 2006 (online)
A short synthesis of the spirohydantoin of glucopyranose 1β [a potent and specific inhibitor of glycogen phosphorylase], together with its inactive anomer 1α, from a readily available heptonolactone is described; this is the first synthesis of a spirohydantoin of a pyranose in which the pyranose ring is formed after the hydantoin ring.
hydantocidin - glycogen phosphorylase - enzyme inhibition - hydantoin - lactone