Synlett 1997; 1997(8): 917-918
DOI: 10.1055/s-1997-950
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Mild and Regiospecific Phosphorylation of Nucleosides

Romualdo Caputo, Annalisa Guaragna, Silvana Pedatella, Giovanni Palumbo*
  • *Dipartimento die Chimica Organica e Biologica, Università di Napoli Federico II, Via Mezzocanone, 16, I-80134 Napoli (Italy), Fax: +39 81 704 1283; e-mail: ctsgroup@cds.unina.it
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Nucleosides are reported to be conveniently phosphorylated by diphenylphosphate previously activated with a triarylphosphine- I2 complex. The reaction is characterised by mild conditions, high yields, easy work-up and purification of the final product. The activation of the phosphorylating agent, unlike Mitsunobu reaction, enables to avoid the usual inversion of configuration at C-3'.