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Synlett 1997; 1997(8): 1013-1014
DOI: 10.1055/s-1997-955
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Novel Parham-type Cycloacylations of 1H-Pyrazole-1-alkanoic Acids

Scott D. Larsen*
  • *Discovery Chemistry Research, Pharmacia & Upjohn, Inc., Kalamazoo, MI 49001, USA
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Publication History

Publication Date:
31 December 2000 (online)

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Exposure of 1H-pyrazole-1-alkanoic acids to two equivalents of n-butyllithium affords the corresponding cyclic ketones via a Parham-type cyclization process. Although yields are modest, this procedure represents a simple and direct intramolecular acylation of a non-nucleophilic pyrazole carbon.

cycloacylation - anionic - Parham - pyrazole - lithiation