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Synlett 1997; 1997(8): 909-910
DOI: 10.1055/s-1997-960
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A Useful Oxidation Procedure for the Preparation of 3-Alkanoyltetronic Acids

Asmita Mittra, Masayuki Yamashita, Ikuo Kawasaki, Hiromichi Murai, Tomomichi Yoshioka, Shunsaku Ohta*
  • *Kyoto Pharmaceutical University, Misasagi-Nakauchicho 5, Yamashinaku, Kyoto 607, Japan, Fax +81(75)5954795; E-mail sohta@mb.kyoto-phb.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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An easy and convenient synthesis of 3-alkanoyl-5-hydroxymethyltetronic acids, the salts of which have inhibitory activity against HIV-1 protease, is described and a new direct route to 1,3-dicarbonylester from cyclic β-ketoester is developed.

tetronic acid - selenide - oxidation - acylation - HIV-1 protease