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Synlett 1997; 1997(8): 983-985
DOI: 10.1055/s-1997-972
DOI: 10.1055/s-1997-972
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Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide
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Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199708/lookinside/thumbnails/10.1055-s-1997-972-1.jpg)
Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subsequent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.
Yamadazyma farinosa - Pseudomonas lipase - enantioselective reduction - kinetic resolution - (R)-5-hexanolide