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Synlett 1997; 1997(10): 1155-1156
DOI: 10.1055/s-1997-978
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A Highly Diastereoselective Intramolecular Hetero Diels-Alder Approach Towards Tetracyclic Pyrazoles

Erik Ceulemans, Marieke Voets, Sabine Emmers, Wim Dehaen*
  • *Department of Chemistry, University of Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium, Fax: ++32 16 327990; e-mail: Wim.Dehaen@hartree.quantchem.kuleuven.ac.be
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Publication History

Publication Date:
31 December 2000 (online)

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A pyrazole aldehyde was used as a starting material for an intramolecular hetero Diels-Alder reaction, affording tetracyclic pyrazoles with high yield and diastereoselectivity. The isoxazolo fused cycloadduct formed interesting spiro-adducts upon heating.

hetero Diels-Alder reaction - cycloaddition - pyrazoles - diastereoselectivity