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Synlett 1997; 1997(10): 1193-1195
DOI: 10.1055/s-1997-989
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One Flask Preparation of Trifluoromethylated Amides from Ketones and Trifluoromethyltrimethylsilane via Ritter Reaction with Nitriles

Emily C. Tongco, G. K. Surya Prakash* , George A. Olah1
  • *Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, CA 90089-1661
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Publication History

Publication Date:
31 December 2000 (online)

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Trifluoromethylated amides are prepared in a simple one-flask reaction via the Ritter reaction of the corresponding trifluoromethylated silyl ethers, which themselves are readily obtained from the starting ketones and trifluoromethyltrimethylsilane. The yields are good to average.

Ritter reaction - (trifluoromethyl)trimethylsilane - trifluoromethylated tertiary amides - hydrolysis - acetonitrile