Download PDF
Synlett 1997; 1997(10): 1153-1154
DOI: 10.1055/s-1997-990
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Lewis Acid-Catalyzed Deprotection of p-Methoxybenzyl Ether

Abderrahim Bouzide, Gilles Sauvé*
  • *Institut Armand-Frappier, 531 boul. de Prairies, Laval, Québec, Canada H7N 4Z3, Fax: (514) 686-5619; E-mail: sauveg@accent.net
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The p-methoxybenzyl protecting group was readily removed from alcohols and phenols using catalytic amounts of AlCl3 or SnCl2•2H2O in the presence of EtSH at room temperature. Under these mild conditions other protecting groups such as methyl and benzyl ethers, p-nitrobenzoyl esters, TBDPS ethers and isopropylidene acetal were unchanged.

p-methoxybenzyl ether - aryl PMB ether - Lewis acid - deprotection