Synlett 1998; 1998(6): 640-642
DOI: 10.1055/s-1998-1734
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Lanthanide Triflate Catalysed Reactions of Acetals with Primary Amines and Cascade Cyclisation Reactions

Harry Heaney* , Michael T. Simcox, Alexandra M. Z. Slawin, Robert G. Giles
  • *Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3TU; Fax + 44(15 09)22 39 25; E-mail: h.heaney@lboro.ac.uk
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Publikationsdatum:
31. Dezember 2000 (online)

The formation of imines from acetals and primary amines can be carried out at significantly lower temperatures using scandium or lanthanide triflates as catalysts, than in the absence of a catalyst: the intermediate aminol ethers can also take part in cascade cyclisation reactions, for example using tryptamine and ethyl tryptophanate.