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Synlett 1998; 1998(10): 1156-1158
DOI: 10.1055/s-1998-1862
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Solid Phase Synthesis of 3-Acyltetramic Acids

Lutz Weber* , Patrick Iaiza, Gérard Biringer, Pierre Barbier
  • *Pharma Division, Preclinical Research, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland; Fax + 49-89-74 00 70 80; E-mail: Lutz.Weber@morphochem.de
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Publication History

Publication Date:
31 December 2000 (online)

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We report a solid-phase synthesis of 3-acyltetramic acids that are components of naturally occurring antibiotics. The products were obtained in satisfactory purity by a novel cyclization-cleavage strategy via a Dieckmann condensation.

combinatorial chemistry - solid phase synthesis - 3-acyltetramic acids - Dieckman-condensation - cyclization-cleavage strategy