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Synlett 1999; 1999(3): 339-341
DOI: 10.1055/s-1999-2602
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Efficient Simultaneous Closure of Polysubstituted 1-Aminopyrrole Rings Spaced by a Variable Number of Methylene Groups

Orazio A. Attanasi* , Lucia De Crescentini, Paolino Filippone, Francesca R. Perrulli, Stefania Santeusanio
  • *Istituto di Chimica Organica della Facoltà di Scienze, Università di Urbino, Piazza della Republica 13, 61029 Urbino, Italy; Fax +39 (07 22) 29 07; E-mail: attanasi@fis.uniurb.it
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Publikationsdatum:
31. Dezember 1999 (online)

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The treatment of alkyl 2-chloroacetoacetate with carbohydrazide, succinic or adipic dihydrazide produces the relevant α,α′-dichlorobishydrazones. In the presence of sodium carbonate, these compounds react at room temperature with β-diketones, β-ketoesters or β-ketoamides to give rise to functionalized 1-carbonyl-aminopyrrole rings spaced by a variable number of methylene groups.

1-aminopyrroles - acyl dihydrazides - 2-chloro-1,3-ketoesters - α,α′-dichlorobishydrazones