PDF herunterladen
Synlett 1999; 1999(6): 810-812
DOI: 10.1055/s-1999-2739
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Rapid Parallel Synthesis of Benzimidazoles

Chih-Ming Yeh* , Chung-Ming Sun
  • *Department of Chemistry, National Dong-Hwa University, 1, Sec. 2, Da-Hsueh Rd; Shou-Feng, Hualien 974, Taiwan; Fax +8 86-3-8 66 17 80; E-mail: cmsun@cc.ndhu.edu.tw
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 1999 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Soluble polymer-supported solution synthesis of 2-alkylthiobenzimidazoles 1 has been developed. Treatment of polymer bound o-fluoronitrobenzene 2 with various primary amines affords o-nitroaniline derivatives. Reduction of the aromatic nitro group followed by cyclization gives a benzimidazole-2-thione 5. Reaction of 5 with alkyl halides followed by cleavage provides final compounds in high yield and high purity after six steps.

benzimidazole - combinatorial chemistry - liquid-phase method - solid-phase method - scaffold