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Synlett 1999; 1999(9): 1456-1458
DOI: 10.1055/s-1999-2835
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N-Bromosuccinimide (NBS) as a Powerful and Chemoselective Catalyst for Acetalization of Carbonyl Compounds under almost Neutral Reaction Conditions

Babak Karimi* , Hassan Seradj, Gholam-Reza Ebrahimian
  • *Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), P.O. Box 45195-159, Gaveh Zang, Zanjan, Iran; Fax + 98(02 41)44 90 23
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Publication Date:
31 December 1999 (online)

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Highly efficient and mild acetalization of various types of carbonyl compounds was achieved using NBS under almost neutral reaction conditions. Due to the neutrality of the medium this method is especially useful for the protection of acid sensitive substrates.

acetals - N-bromosuccinimide - carbonyl compounds - protecting groups - catalyst