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Synlett 1999; 1999(10): 1579-1581
DOI: 10.1055/s-1999-2910
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Palladium Catalyzed Bispyrimidine Thioether Synthesis

Molly S. Harr* , Alice L. Presley, Atli Thorarensen
  • *Medicinal Chemistry I, Pharmacia and Upjohn, 301 Henrietta Street, Kalamazoo, MI 49001, USA; Fax (6 16)-8 33-22 32; E-mail: atli.thorarensen@am.pnu.com
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Publication Date:
31 December 1999 (online)

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The synthesis of sulfur-bridged bispyrimidines via coupling of a halopyrimidine and pyrimidine thiolate anion has been explored utilizing a palladium catalyzed cross coupling reaction. Several reaction parameters including stoichiometry and choice of solvent have been optimized. These reaction conditions have allowed for the preparation of a wide range of functionalized bispyrimidines.

catalysis - palladium - pyrimidines - thioethers