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Synlett 1999; 1999(11): 1838-1840
DOI: 10.1055/s-1999-2925
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Stereoselective α-Alkylation of New Chiral Auxiliaries: An Access to Enantiomerically Pure α- and α,β-Substituted β-Amino Acids

Claude Agami* , Sandrine Cheramy, Luc Dechoux
  • *Laboratoire de Synthèse Asymétrique associé au CNRS, Université Pierre et Marie Curie, 5 place Jussieu, 75005 Paris, France; Fax (33) 01 44 27 26 20; E-mail: dechoux@ccr.jussieu.fr
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Publication Date:
31 December 1999 (online)

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New bicyclic heterocycles 5, which are potentially useful for the enantioselective synthesis of substituted β-amino acids, have been synthesized. A study on the α-alkylation of these chiral auxiliaries is presented. An optically pure β-amino acid was obtained in excellent yield from its masked chiral derivative 6a.

β-amino acids - chiral auxiliary - asymmetric synthesis