A Novel Strategy for the Automated Synthesis of Bis-amides of 1,2-Diamines

Takayuki Doi; Ichiro Hijikuro; Takashi Takahashi

doi:10.1055/s-1999-2947

Synlett 1999; 1999(11): 1751-1753
DOI: 10.1055/s-1999-2947

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A Novel Strategy for the Automated Synthesis of Bis-amides of 1,2-Diamines

Takayuki Doi^* , Ichiro Hijikuro, Takashi Takahashi

^*Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan; Fax +81-3-57 34-28 84; E-mail: ttakashi@o.cc.titech.ac.jp

Abstract

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An automated synthesis of bis-amides from 1,2-diamines and acids was accomplished on solid-phase via selective formation of an aminoacetal of the diamine with a well-tuned polymer-supported aldehyde linker, diamidation on the polymer-supported aminoacetal, with acid-cleavage to yield product.

amides - amines - combinatorial chemistry - condensation - solid-phase synthesis

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