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Synlett 1999; 1999(12): 1933-1935
DOI: 10.1055/s-1999-2962
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A Novel Approach to the Solid-Phase Synthesis of (Acyloxy)methyl Ketones

M. Teresa Mujica* , Günther Jung
  • *Institut für Organische Chemie, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 18, D-72076 Tübingen, Germany; Fax + 49(70 71)29 55 60; E-mail: guenther.jung@uni.tuebingen.de
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Publication Date:
31 December 1999 (online)

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A procedure for the preparation of (acyloxy)methyl ketones on a solid support is reported. The key step in the synthesis includes an efficient hydrohalogenation reaction of aspartyl diazomethyl ketone compatible with Wang-resin.

solid-phase synthesis - diazomethyl ketones - (acyloxy)methyl ketones - peptide-mimetics - Interleukin 1β-Converting Enzyme inhibitors