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Synlett 2000; 2000(1): 45-48
DOI: 10.1055/s-2000-6446
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Solid Phase Synthesis of Substituted 2,3-Dihydroquinolin-4-ones

Sebastian Wendeborn*
  • *Novartis Crop Protection AG, Basel, Switzerland; Fax + 41-61-697-5500; E-mail: sebastian.wendeborn@cp.novartis.com
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Publikationsdatum:
31. Dezember 2000 (online)

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A highly flexible method for solid phase synthesis of substituted 2,3-dihydroquinolin-4-ones has been developed. Two points of diversity can be introduced through the use of Grignard reagents and amines; a third position can be modified through two novel, oxidative cleavage reactions. Most compounds are obtained in purities exceeding 85%.

combinatorial chemistry - polystyrene - Grignard addition to quinolines - urea formation - enol ether fluorination - enol ether epoxidation