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Synlett 2000; 2000(3): 355-356
DOI: 10.1055/s-2000-6523
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A One-Pot Synthesis of Tetrahydroisoquinolonic Acids from Aldehydes and Amines in Trimethylorthoformate

Niefang Yu* , Rebecca Poulain, Jean-Claude Gesquiere
  • *Laboratoire de Chimie Organique, Faculté de Pharmacie, UMR CNRS 8525 and Institut Pasteur de Lille, 3 rue du Professeur Languesse, 59006 Lille, France; Fax +33 3 20 96 40 22; E-mail: jcgesqui@phare.univ-lille2.fr
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Publication Date:
31 December 2000 (online)

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Tetrahydroisoquinolonic acids are synthesized in the presence of excess trimethyl orthoformate by a one-pot procedure directly from the corresponding amines, aldehydes and homophthalic anhydride.

cyclization - amines - aldehydes - solvent effect - orthoformate