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Synlett 2000; 2000(4): 556-558
DOI: 10.1055/s-2000-6585
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Reductive Amination Promoted by Tributyltin Hydride

Toshihiro Suwa* , Erika Sugiyama, Ikuya Shibata, Akio Baba
  • *Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Fax +81-6-68 79-73 87; E-mail: shibata@ap.chem.eng.osaka-u.ac.jp
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Publication Date:
31 December 2000 (online)

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Reductive amination of carbonyl compounds with primary and secondary ammonium salts was performed by tributyltin hydride in DMF solvent at room temperature. A variety of secondary and tertiary amines including sterically hindered ones could be synthesized in one-pot procedure. No side reaction such as the reduction of starting carbonyl or overalkylation was detected.

reductive amination - tin hydride - ammonium salt - amine