PDF herunterladen
Synlett 2000; 2000(5): 0707-0709
DOI: 10.1055/s-2000-6635
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Efficient Preparation of α-Alkylidene-β-formylmethyl-γ-lactams via Pd(II)-Catalyzed Intramolecular Alkyne-α,β-Unsaturated Carbonyl Coupling

Xu Xie* , Xiyan Lu
  • *Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China; Fax 86-21-64166128; E-mail: xylu@pub.sioc.ac.cn
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

An efficient stereoselective cyclization method by palladium(II)-catalyzed intramolecular enyne coupling of N-(3′-formylallylic) alkynamides was developed to yield α-alkylidene-β-formylmethyl-γ-lactams. The substitution pattern of the triple bond determines the β,γ-relative stereochemistry of the lactam product.

coupling - diastereoselectivity - enynes - lactams - palladium