PDF herunterladen
Synlett 2000; 2000(6): 0829-0831
DOI: 10.1055/s-2000-6718
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Convenient Synthesis of Heteroaryl Benzoic Acids via Suzuki Reaction

Yong Gong* , Henry W. Pauls
  • *Department of Medicinal Chemistry, Rhone-Poulenc Rorer, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA; Fax 610 454 3311; E-mail: yong.gong@aventis.com
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

An one step approach to heteroaryl benzoic acids from readily accessible heteroaryl halides and carboxybenzene boronic acids is described. The Suzuki coupling is carried out in the presence of Pd(PPh3)4 and sodium carbonate in aqueous acetonitrile. The scope and limitations of the reaction are discussed.

biaryls - carboxylic acids - cross-coupling - heteroaryl halides - palladium