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Synlett 2000; 2000(8): 1190-1192
DOI: 10.1055/s-2000-6746
DOI: 10.1055/s-2000-6746
letter
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The First Synthesis of the Bis(indole) Marine Alkaloid Rhopaladin D
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
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The first synthesis (six steps) of the bis(indole) alkaloid Rhopaladin D isolated from the marine tunicate Rhopalaea sp. is described. The key step, construction of the central imidazolinone ring, is based on the aza-Wittig reaction of the iminophosphorane derived from the α-azido-β-(3-indolyl)propenamide and indolyl-3-glyoxylyl chloride in the presence of polymer-supported BEMP as a base.
rhopaladins - marine alkaloid - bis(indole) - aza-Wittig reaction - iminophosphorane