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Synlett 2000; 2000(9): 1363-1365
DOI: 10.1055/s-2000-7137
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Synthesis of Model of Phomopsin-Ustiloxin-Type Antimitotic Agents

Taoues Laïb* , Jieping Zhu
  • *Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France; Fax (33)-1-69 07 72 47; E-mail: zhu@icsn.cnrs-gif.fr
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Publication Date:
31 December 2000 (online)

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An intramolecular SNAr reaction was applied to the synthesis of a 13-membered meta-cyclophane that is the structural core of phomopsin and ustiloxin-type antimitotics. Two types of facile β-elimination processes are also documented.

phomopsin - ustiloxin - intramolecular SNAr reaction - cyclophane - macrocycle - β-elimination