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Synlett 2000; 2000(10): 1488-1490
DOI: 10.1055/s-2000-7644
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Facile Cyanomethylation of Bromopyridines by Nucleophilic Substitution with Lithioacetonitrile

Renato T. Skerlj* , David Bogucki, Gary J. Bridger
  • *AnorMED Inc., #200-20353 64th Ave, Langley, BC, V2Y 1N5 Canada; Fax + 1 (6 04)-530-09 76; E-mail: rskerlj@anormed.com
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Publikationsdatum:
31. Dezember 2000 (online)

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Substituted bromopyridines undergo facile nucleophilic substitution with lithioacetonitrile under mild conditions to afford the corresponding cyanomethylated products.

cyanomethylation - bromopyridines - halopyridines - aromatic nucleophilic substitution - lithioacetonitrile