Abstract
Four new cytotoxic neolignans, machilusol A (1), machilusol C (3), machilusol D (4), machilusol E (5) as well as two new inactive neolignans, machilusol B (2) and machilusol F (6), were isolated from the stem wood of Machilus obovatifolia. All structures were identified by means of spectroscopic analysis.
Key words
Machilus obovatifolia
-
Persea obovatifolia
- Lauraceae, stem wood - neolignan - machilusol A - F - cytotoxicity
References
-
1 Liao J C.. Lauraceae in Flora of Taiwan, Editorial Committee of the Flora of Taiwan, 2nd edn., Vol. II, Taipei, Taiwan,; 1996: 481-2
-
2 Chang C E.. Lauraceae in Flora of Taiwan, Editorial Committee of the Flora of Taiwan, Epoch Publishing Co., 1st edn., Vol. II, Taipei, Taiwan,; 1976: 460-2
-
3
Tsai I L,, Hsieh C F,, Duh C Y,, Chen I S..
Cytotoxic neolignans from Persea obovatifolia.
.
Phytochemistry.
1996;;
43
1261-3
-
4
Tsai I L,, Hsieh C F,, Duh C Y..
Additional cytotoxic neolignans from Persea obovatifolia.
.
Phytochemistry.
1998;;
48
1371-5
-
5
Tsai I L,, Hsieh C F,, Duh C Y,, Chen I S..
Further study on the chemical constituents and their cytotoxicity from the leaves of Persea obovatifolia.
.
The Chinese Pharmaceutical Journal.
1999;;
51
335-45
-
6
Mosmann T..
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
Journal of Immunological Methods.
1983;;
65
55-63
-
7
Pintao A M,, Pais M SS,, Coley H,, Kelland L R,, Judson I R..
In vitro and in vivo antitumor activity of benzyl isothiocyanate: A natural product from Tropaeolum majus.
.
Planta Medica.
1995;;
61
233-6
-
8
Chen J J,, Ishikawa T,, Duh C Y,, Tsai I L,, Chen I S..
New dimeric aporphine alkaloids and cytotoxic constituents of Hernandia nymphaeifolia.
.
Planta Medica.
1996;;
62
528-33
-
9
Ito K,, Ichino K,, Iida T,, Lai J..
Neolignans from Magnolia kachirachirai.
.
Phytochemistry.
1984;;
23
2643-5
-
10
Nabeta K,, Hirata M,, Ohki Y,, Samaraweera S WA,, Okuyama H..
Lignans in cell cultures of Picea glehnii.
.
Phytochemistry.
1994;;
37
409-13
-
11
Shimomura H,, Sashida Y,, Oohara M..
Lignans from Machilus thunbergii.
.
Phytochemistry.
1987;;
26
1513-5
-
12
Achenbach H,, Grob J,, Dominguez X A,, Cano G,, Star J V,, Brussolo L DC,, Munoz G,, Salgado F,, Lopez L..
Lignans, neolignans and norneolignans from Krameria cystisoides.
.
Phytochemistry.
1987;;
26
1159-66
-
13
Ferri P H,, Barata L ES..
Neolignans and a phenylpropanoid from Virola pavonis leaves.
Phytochemistry.
1992;;
31
1375-7
-
14
Forrest J E,, Heacock R A,, Forrest T P..
Diarylpropanoids from nutmeg and marce (Myristica fragrans Hout.).
Journal of the Chemical Socciety Perkin Transactions.
I 1974:;
205-9
-
15
Hada S,, Hattori M,, Tezuka Y,, Kikuchi T,, Namba T..
New neolignans and lignans from the aril of Myristica fragrans.
.
Phytochemistry.
1988;;
27
563-8
D. Ph. Prof. Ian-Lih Tsai
Graduate Institute of Natural Products Kaohsiung Medical University
Kaohsiung, Taiwan
Republic of China
Email: ialits@cc.kmu.edu.tw
Phone: 886-7-321-0683