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DOI: 10.1055/s-2000-8624
Inducible Nitric Oxide Synthase Inhibitors from Saposhnikovia divaricata and Panax quinquefolium
Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
![](https://www.thieme-connect.de/media/plantamedica/200007/lookinside/thumbnails/10.1055-s-2000-8624-1.jpg)
Abstract
A series of polyacetylenes, falcarinone, panaxynol, falcarindiol, panaxydol, and panaxytriol, were isolated from Saposhnikovia divaricata (Turcz.) Schischk and Panax quinquefolium L. These polyacetylenes were identified as active principles on the inhibition of nitrite production by inducible nitric oxide synthase (iNOS). Treatment with 10 μM of panaxynol, falcarindiol, panaxydol and panaxytriol decreased the LPS/IFN-γ-stimulated accumulation of nitrite by 71.92 ± 3.07, 69.95 ± 3.68, 45.48 ± 6.11 and 36.85 ± 8.80 %, respectively. The IC50 value of falcarinone, panaxynol, falcarindiol, panaxydol and panaxytriol was > 20, 2.23, 1.98, 6.58 and 9.85 μM, respectively.
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Dr. Yun-Lian Lin
National Research Institute of Chinese Medicine
No. 155-1, Sec. 2
Li Nung St.
Taipei 112
Taiwan, ROC
eMail: yllin@cma23.nricm.edu.tw
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