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DOI: 10.1055/s-2001-10877
Molluscicidal and Trypanocidal Activities of Lapachol Derivatives
Publikationsverlauf
Publikationsdatum:
31. Dezember 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200101/lookinside/thumbnails/10.1055-s-2001-10877-1.jpg)
Abstract
The activity of the potassium salt of lapachol against the snail Biomphalaria glabrata and its egg masses was tested. The obtained IC50 values (2.70 ppm and 1.43 ppm, respectively) are indicative of a strong activity. Lapachol derivatives were also assayed against infective trypomastigote blood forms of T. cruzi and the triacetoxy derivative of reduced lapachol showed relevant trypanocidal activity, killing 95.7 % of the parasites at the concentration of 42 μg/mL.
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Marília Oliveira Fonseca Goulart
Departamento de Química
Centro de Ciências Exatas e Naturais
Universidade Federal de Alagoas
Tabuleiro do Martins
Maceió, Alagoas, 57072-970
Brasil
eMail: mofg@qui.ufal.br;
Telefon: 005582-2141389