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Planta Med 2001; 67(1): 92-93
DOI: 10.1055/s-2001-10877
Letter
Georg Thieme Verlag Stuttgart · New York

Molluscicidal and Trypanocidal Activities of Lapachol Derivatives

Aldenir Feitosa dos Santos1 , Patrícia A. L. Ferraz1 , Fabiane Caxico de Abreu1, 2 , Égler Chiari3 , Marília O. F. Goulart1,*, Antônio Euzébio G. Sant’Ana1
  • 1 Departamento de Química/CCEN, UFAL, Maceió, Alagoas, Brazil
  • 2 Departamento de Química Fundamental, UFPE, Recife, Pernambuco, Brazil
  • 3 Departamento de Parasitologia, ICB, UFMG, Belo Horizonte, Minas Gerais, Brazil
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Publication History

Publication Date:
31 December 2001 (online)

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Abstract

The activity of the potassium salt of lapachol against the snail Biomphalaria glabrata and its egg masses was tested. The obtained IC50 values (2.70 ppm and 1.43 ppm, respectively) are indicative of a strong activity. Lapachol derivatives were also assayed against infective trypomastigote blood forms of T. cruzi and the triacetoxy derivative of reduced lapachol showed relevant trypanocidal activity, killing 95.7 % of the parasites at the concentration of 42 μg/mL.

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Marília Oliveira Fonseca Goulart

Departamento de Química

Centro de Ciências Exatas e Naturais

Universidade Federal de Alagoas

Tabuleiro do Martins

Maceió, Alagoas, 57072-970

Brasil

Email: mofg@qui.ufal.br;

Phone: 005582-2141389