Molluscicidal and Trypanocidal Activities of Lapachol Derivatives

Abstract

The activity of the potassium salt of lapachol against the snail Biomphalaria glabrata and its egg masses was tested. The obtained IC₅₀ values (2.70 ppm and 1.43 ppm, respectively) are indicative of a strong activity. Lapachol derivatives were also assayed against infective trypomastigote blood forms of T. cruzi and the triacetoxy derivative of reduced lapachol showed relevant trypanocidal activity, killing 95.7 % of the parasites at the concentration of 42 μg/mL.

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