Antioxidanzien in der Ernährung und Arteriosklerose

H. Hauner; B. Watzl

doi:10.1055/s-2001-11318

DMW - Deutsche Medizinische Wochenschrift, Inhaltsverzeichnis

Dtsch Med Wochenschr 2001; 126(8): 213-217
DOI: 10.1055/s-2001-11318

Übersichten

Antioxidanzien in der Ernährung und Arteriosklerose

H. Hauner¹ , B. Watzl²

¹Deutsches Diabetes-Forschungsinstitut (Ärztlicher Dirketor: Prof. Dr. W.A. Scherbaum) an der Heinrich-Heine-Universität Düsseldorf
²Institut für Ernährungsphysiologie (Leiter: Prof. Dr. G. Rechkemmer), Bundesforschungsanstalt für Ernährung, Karlsruhe

Abstract

Volltext

Referenzen

Literatur

1 Ascherio A, Rimm E B, Hernan M A. et al . Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann Intern Med. 1999; 130 963-970
2 Blot W J, Li J Y, Taylor P R. et al . Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993; 85 1483-1492
3 Bub A, Watzl B, Abrahamse S L. Moderate intervention with carotinoid-rich vegetable products reduce lipid peroxidation in healthy volunteers. J Nutr. 2000; 130 2200-2206
4 Castelluccio C, Bolwell G P, Gerrish C, Rice-Evans C A. Differential distribution of ferulic acid to the major plasma constituents in relation to its potential as an antioxidant. Biochem J. 1996; 316 691-694
5 Cook N C, Samman S. Flavonoids - Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem. 1996; 7 66-76
6 DACH .Referenzwerte für die Nährstoffzufuhr. 1. Auflage. Frankfurt, Umschau Braus GmbH Verlagsgesellschaft 2000
7 Diaz M N, Frei B, Vita J A, Keaney J F. Antioxidants and atherosclerotic heart disease. N Engl J Med. 1997; 337 408-416
8 Enstrom J E, Kanim L E, Klein M A. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992; 3 194-202
9 Gale C R, Martyn C N, Winter P D, Cooper C. Vitamin C and risk of death from stroke and coronary heart disease in a cohort of elderly people. Br Med J. 1995; 310 1563-1566
10 Geleijnse J M, Launer L J, Hofman A, Pols H A, Witteman J C. Tea flavonoids may protect against atherosclerosis: the Rotterdam Study. Arch Intern Med. 1999; 159 2170-2174
11 GISSI-Prevenzione Investigators . Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Lancet. 1999; 354 447-455
12 Graf E. Antioxidant potential of ferulic acid. Free Radical Biol Med. 1992; 13 435-448
13 Heitzer T, Yla Herttuala S, Wild E, Luoma J, Drexler H. Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both. J Am Coll Cardiol. 1999; 33 499-505
14 Hertog M G, Sweetnam P M, Fehily A M. et al . Antioxidant flavonols and ischaemic heart disease in a Welsh population of men: The Caerphilly Study. Am J Clin Nutr. 1997; 65 1489-1494
15 Hertog M G, Feskens E JM, Hollman P CH. et al . Dietary antioxidant flavonoids and risk of coronary heart disease. The Zuphten Elderly Study. Lancet. 1993; 342 1007-1011
16 Hodgson J M, Puddey I B, Croft K D, Mori T A, Rivera J, Beilin L J. Isoflavonoids do not inhibit in vivo lipid peroxidation in subjects with high-normal blood pressure. Atherosclerosis. 1999; 145 167-172
17 Joshipura K J, Ascherio A, Manson J E. et al . Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA. 1999; 282 1233-1239
18 Keli S O, Hertog M L, Feskens E JM. et al . Dietary flavonoids, antioxidant vitamins, and incidence of stroke. Arch Intern Med. 1996; 156 637-642
19 Klipstein-Grobusch K, Launer L J, Geleijnse J M, Boeing H, Hofman A, Witteman J C. Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis. 2000; 148 49-56
20 Klipstein-Grobush K, Geleijnse J M, den Breeijen J H. et al . Dietary antioxidants and risk of myocardial infarction in the elderly: The Rotterdam Study. Am J Clin Nutr. 1999; 69 261-266
21 Knekt P, Jarvinen R, Reunanen A. et al . Flavonoid intake and coronary mortality in Finland: a cohort study. Br Med J. 1996; 312 478-481
22 Knekt P, Reunanen A, Jarvinen R, Seppanen R, Heliovaara M, Aromaa A. Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol. 1994; 139 1180-1190
23 Kohlmeier L, Kark J D, Gomez-Gracia E. et al . Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol. 1997; 146 618-626
24 Kushi L H, Folsom A R, Prineas R J, Mink P J, Ying W, Bostick R M. Dietary antioxidant vitamins and death from coronary heart disease in postemnopausal women. N Engl J Med. 1996; 334 1156-1162
25 Law M R, Morris J K. By how much does fruit and vegetable consumption reduce the risk of ischaemic heart disease?. Eur J Clin Nutr. 1998; 52 549-556
26 Lengfelder W. Antioxidative Vitamine: Prävention von kardiovaskulären Erkrankungen. Dtsch Med Wschr. 1998; 123 1014-1017
27 Martin K R, Wu D, Meydani M. The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells. Atherosclerosis. 2000; 150 265-274
28 Miller N J, Sampson J, Candeias L P, Bramley P M, Rice-Evans C A. Antioxidant activities of carotenes and xanthophylls. FEBS Lett. 1996; 384 240-242
29 Morris D L, Krichevsky S B, Davis C E. Serum carotenoids and coronary heart disease. The Lipid Research Clinics Coronary Primary Prevention Trial and Follow-up. JAMA. 1994; 272 1439-1441
30 Morton L W, Abu-Amsha C R, Puddey I B, Croft K D. Chemistry and biological effects of dietary phenolic compounds: Relevance to cardiovascular disease. Clin Exp Pharmacol Physiol. 2000; 27 152-159
31 Nardini M, Natella F, Gentili V, DiFelice M, Scaccini C. Effect of caffeic acid dietary supplementation on the antioxidant defense system in rat: An in vivo study. Arch Biochem Biophys. 1997; 342 157-160
32 Omenn G S, Goodman G E, Thornquist M D. et al. . Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996; 334 1150-1155
33 Paolisso G, Esposito R, D’Alessio M A, Barbieri M. Primary and secondary prevention of atherosclerosis: is there a role for antioxidants?. Diabetes Metab. 1999; 298 306
34 Rapola J M, Virtamo J, Ripatti S. et al . Randomised trial of (α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet. 1997; 349 1715-1720
35 Rice-Evans C A, Miller N J, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biol Med. 1996; 20 933-956
36 Rimm E, Katan M B, Ascherio A. et al . Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Ann Intern Med. 1996; 125 384-389
37 Rimm E B, Stampfer M J, Ascherio A, Giovannucci E, Colditz G A, Willett W C. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993; 328 1450-1456
38 Samman S, Lyons W all PM, Chan G S, Smith S J, Petocz P. The effect of supplementation with isoflavons on plasma lipids and oxidisability of low density lipoprotein in premenopausal women. Atherosclerosis. 1999; 147 277-283
39 Solzbach U, Horning B, Jeserich M, Just H. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation. 1997; 96 1513-1519
40 Stampfer M J, Hennekens C H, Manson J E, Colditz G A, Rosner B, Willett W C. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 1993; 328 1444-1449
41 Stephens N G, Parsons A, Schofield P M. et al . Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet. 1996; 347 781-786
42 Tardif J -C, Cote G, Lesperance J. et al. Multivitamins and Probucol Study Group . Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. N Engl J Med. 1997; 337 365-372
43 The Heart Outcomes Prevention Evaluation Study Investigators . Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med. 2000; 342 154-160
44 Tikkanen M J, Wähälä K, Ojala S, Vihma V, Adlercreutz H. Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci USA. 1998; 95 3106-3110
45 Ting H H, Timini F K, Haley E A, Roddy M A, Ganz P, Creager M A. Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Circulation. 1997; 95 2617-2622
46 Todd S, Woodward M, Tunstall-Pedoe H, Bolton-Smith C. Dietary antioxidant vitamins and fiber in the etiology of cardiovascular disease and all-causes mortality: results from the Scottish Heart Health Study. Am J Epidemiol. 1999; 150 1073-1080
47 Vanharanta M, Voutilainen S, Lakka T A, van der Lee M, Adlercreutz H, Salonen J T. Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet. 1999; 354 2112-2115
48 Watzl B, Leitzmann C. Bioaktive Substanzen in Lebensmitteln. 2. Auflage. Stuttgart, Hippokrates Verlag 1999
49 Wiseman H, O’Reilly J D, Adlercreutz H. et al . Isoflavons phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of low-density lipoproteins to oxidation in humans. Am J clin Nutr. 2000; 72 395-400
50 Yochum L, Kushi L H, Meyer K, Folsom A R. Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women. Am J Epidemiol. 1999; 149 943-949

Korrespondenz

Prof. Dr. Hans Hauner

Deutsches Diabetes-Forschungsinstitut an der Heinrich-Heine-Universität

Auf’m Hennekamp 65

40225 Düsseldorf

Telefon: 0211/33821

Fax: 0211/3382-339

eMail: hauner@dfi.uni-duesseldorf.de