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Semin Neurol 2001; 21(1): 033-040
DOI: 10.1055/s-2001-13117
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Multiple System Atrophy

G. K. Wenning, K. Seppi, C. Scherfler, N. Stefanova, Z. Puschban
  • Universitätsklinik für Neurologie, Innsbruck, Austria
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Publikationsverlauf

Publikationsdatum:
31. Dezember 2001 (online)

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ABSTRACT

Multiple system atrophy (MSA) is an adult-onset sporadic progressive neurodegenerative disorder of unknown etiology. It is clinically characterized by the variable combination of autonomic failure, parkinsonism, cerebellar ataxia, and pyramidal signs. The present review summarizes up-to-date knowledge on the clinical diagnosis and molecular pathology of MSA. We also review the role of additional investigations that may support a clinical diagnosis of MSA. Finally, we briefly discuss the management of MSA, focusing on possible future therapeutic strategies.

KEYWORD

Multiple system atrophy - differential diagnosis - therapy

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