Download PDF
Synlett 2001; 2001(6): 0745-0748
DOI: 10.1055/s-2001-14906
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Solid-Phase Synthesis of Glyco-Oligonucleotide Conjugates

Matteo Adinolfi* , Lorenzo De Napoli, Giovanni Di Fabio, Luigi Guariniello, Alfonso Iadonisi, Anna Messere, Daniela Montesarchio, Gennaro Piccialli
  • *Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli "Federico II", Complesso Universitario di Monte S. Angelo, Via Cynthia 4, 80126 Napoli, Italy; Fax 39-081-67 43 93; E-mail: picciall@unina.it
Further Information

Publication History

Publication Date:
31 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

The first examples of direct glycosidation of the 5′-OH end of polypyrimidine oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successfully isolate the target 5′-glycosyl derivatives. A 3′,5′-diglucosylated 16-mer oligonucleotide has also been obtained.

glycosidation - nucleic acids analogs - solid phase synthesis

      >