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Synlett 2001; 2001(6): 0745-0748
DOI: 10.1055/s-2001-14906
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Solid-Phase Synthesis of Glyco-Oligonucleotide Conjugates

Matteo Adinolfi* , Lorenzo De Napoli, Giovanni Di Fabio, Luigi Guariniello, Alfonso Iadonisi, Anna Messere, Daniela Montesarchio, Gennaro Piccialli
  • *Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli "Federico II", Complesso Universitario di Monte S. Angelo, Via Cynthia 4, 80126 Napoli, Italy; Fax 39-081-67 43 93; E-mail: picciall@unina.it
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Publication Date:
31 December 2001 (online)

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The first examples of direct glycosidation of the 5′-OH end of polypyrimidine oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successfully isolate the target 5′-glycosyl derivatives. A 3′,5′-diglucosylated 16-mer oligonucleotide has also been obtained.

glycosidation - nucleic acids analogs - solid phase synthesis