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Synlett 2001; 2001(Special Issue): 0983-0985
DOI: 10.1055/s-2001-14912
DOI: 10.1055/s-2001-14912
letter
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A Ligand-Accelerated Chiral Lewis Acid Catalyst in Asymmetric Michael Addition of Thiols to α,β-Unsaturated Carbonyls
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2001 (online)
![](https://www.thieme-connect.de/media/synlett/2001SpecialIssue/lookinside/thumbnails/10.1055-s-2001-14912-1.jpg)
A novel chiral hafnium catalyst, which was readily prepared from Hf(OTf)4 and chiral ligand 1, has been developed in asymmetric Michael reactions of thiols with 3-(2-alkenoyl)-2-oxazolidinones, affording the corresponding adducts in high yields and enantiomeric excesses. Although chiral Lewis acids are less reactive than their original Lewis acids in many cases, ligand-acceleration has been demonstrated in this asymmetric Michael addition reaction.
Lewis acid - Michael reaction - asymmetric catalysis