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Synlett 2001; 2001(7): 1155-1157
DOI: 10.1055/s-2001-15142
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A Purely Synthetic, Diversity Amenable Version of Norephedrine Thiols for the Highly Enantioselective Diethylzinc Addition to Aldehydes

Ciril Jimeno* , Alberto Moyano, Miquel A. Pericàs, Antoni Riera
  • *Unitat de Recerca en Síntesi Asimètrica. Departamento de Química Orgànica. Universitat de Barcelona. c/Martí i Franquès 1-11, E-08028 Barcelona, Spain; Fax (+ 34) 933 397 878; E-mail: mapericas@qo.ub.es
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Publication Date:
31 December 2001 (online)

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A new β-aminothiol arising from purely synthetic yet enantiopure aminoalcohols has been prepared and successfully used in the addition of diethylzinc to aromatic aldehydes, yielding secondary alcohols in ee's up to 99%.

aminothiols - diethylzinc additions - enantioselective - catalytic - aziridinium salt