Synthesis 2001(10): 1471-1478
DOI: 10.1055/s-2001-16076
PAPER
© Georg Thieme Verlag Stuttgart · New York

Desymmetrization Reactions: A Convenient Synthesis of Aromatic Diamide Diamines

Claude Picard*, Nathalie Arnaud, Pierre Tisnès
Laboratoire de Synthèse et Physicochimie de Molécules d"Intérêt Biologique, CNRS UMR 5068, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse cedex 04, France
Fax: +33(5)61556011; e-Mail: picard@chimi.ups-tlse.fr;
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Publikationsverlauf

Received 29 January 2001
Publikationsdatum:
23. September 2004 (online)

Abstract

A two-step process for the synthesis of various diamide diamines derived from 1,n-diamino benzene compounds is described. The amidation reaction is simple, mild, involves readily available bis(N-acylthiazolidine-2-thione) derivatives as acylating agents and requires only stoichiometric equivalents of diamine and acylating agents.

1

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