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Synthesis 2001(10): 1505-1508
DOI: 10.1055/s-2001-16087
DOI: 10.1055/s-2001-16087
PAPER
© Georg Thieme Verlag Stuttgart · New York
Regiospecific Cyclization of β-Methoxyvinyl Trifluoromethyl Ketones with Aminoguanidine: A Convenient Method to Obtain Trifluoromethylated 2-[1H-Pyrazol-1-yl]pyrimidines
Further Information
Received
10 October 2000
Publication Date:
23 September 2004 (online)
Publication History
Publication Date:
23 September 2004 (online)
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Abstract
The regiospecific one-pot synthesis of a novel series of 6-alkyl(aryl)-2-[3-alkyl(aryl)-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazol-l-yl]-4-trifluoromethylpyrimidines 2 and 6-alkyl(aryl)-2-[3-alkyl(aryl)-5-trifluoromethyl-1H-pyrazol-l-yl]- 4-trifluoromethylpyrimidines 3 from 4-alkyl(aryl)-1,1,1-trifluoro-4-methoxyalk-3-en-2-ones 1 and aminoguanidine bicarbonate is reported.
Key words
pyrimidines - pyrazoles - 2-(pyrazolyl)pyrimidines - trifluoromethyl vinyl ketones
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