Planta Med 2001; 67(6): 555-557
DOI: 10.1055/s-2001-16471
Letter

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Cyclopenta[b]benzofuran Derivatives from the Stem Bark of Aglaia formosana

Shang-Kwei Wang1 , Chang-Yih Duh2,*
  • 1 Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan
  • 2 Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan
Weitere Informationen

Publikationsverlauf

August 18, 2000

October 22, 2000

Publikationsdatum:
17. August 2001 (online)

Abstract

A new cytotoxic cyclopenta[b]benzofuran derivative, aglaiformosanin (1) and three known cyclopenta[b]benzofuran derivatives (2 - 4) were isolated from the stem bark of Aglaia formosana. Compounds 1 - 4 exhibited potent cytotoxicity against the P-388, KB, HT-29, HL-60, and A549 cell lines. The structure of compound 1 was determined by spectroscopic analysis.

References

  • 1 Duh C-Y, Wang S-K, Hou R-S, Wu Y-C, Wang Y, Cheng M-C, Chang T T. Dehydroodorin, a cytotoxic diamide from the leaves of Aglaia formosana .  Phytochemistry. 1993;  34 857-8
  • 2 Geran R I, Greenberg N H, MacDonald M M, Schumacher A M, Abbott B J. Protocols for screening chemical agents and natural products against tumors and other biological systems.  Cancer Chemotherapy Reports. 1972;  Part 3 (3) 1-91
  • 3 Hou R-S, Duh C-Y, Chiang M Y, Lin C-N. Sinugibberol, a new cytotoxic cembranoid diterpene from the soft coral Sinulara gibberosa .  Journal of Naturnal Products. 1995;  58 1126-30
  • 4 Kokpol U, Venaskulchai B, Simpson J, Weaver R T. Isolation and X-ray structure determination of a novel pyrimidinone from Aglaia odorata .  Journal of Chemical Society, Chemical Communication. 1994;  773-4
  • 5 Cui B, Chai H, Santisuk T, Reutrakul V, Fansworth N R, Cordell G A, Pezzuto J M, Kinghorn A D. Novel cytotoxic 1H-cyclopenta[b]bezofuran lignans from Aglaia elliptica .  Tetrahedron. 1997;  53 17625-32
  • 6 King M-L, Chang C-C, Ling H-C, Fujita E, Ochiai M, McPhail A T. X-ray crystal structure of rocaglamide, a novel antineukemic 1H-cyclopenta[b]bezofuran from Aglaia elliptifolia .  Journal of Chemical Society, Chemical Communication. 1982;  1150-1
  • 7 Nugroho B W, Edrada R A, Güssrengen V, Wary V, Witte L, Proksch P. An insecticidal rocaglamide derivatives and related compounds from Aglaia odorata (Meliaceae).  Phytochemistry. 1997;  44 1455-61
  • 8 Duh C-Y, Wang S-K, Weng Y-L, Chiang M, Dai C-F. Cytotoxic terpenoids from the Formosan soft coral Nephthea brassica .  Journal of Natural Products. 1992;  62 1518-21
  • 9 Chen J-J, Duh C-Y, Chen I-S. New tetrahydroprotobernerine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi .  Planta Medica. 1999;  65 643-7

Prof. Dr. Chang-Yih Duh

Department of Marine Resources

National Sun Yat-sen University

Kaohsiung 804

Taiwan

Republic of China

eMail: yihduh@mail.nsysu.edu.tw

Fax: +886-75255020