The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC50 value of 6.2 μg/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crystallographic analysis.
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