Partial left ventriculectomy is a new surgical option quickly introduced into clinical use worldwide for treating end-stage heart failure in patients with dilated cardiomyopathy. Due to the overwhelming success of this new kind of surgical treatment for dilated cardiomyopathy, experimental research on the physiological and pathophysiological basis was initially not performed. Now, demands for an appropriate animal model have arisen more and more since the outcome of patients treated by partial left ventriculectomy has differed considerably. This review summarizes available experimental models for heart failure in large animals, and discusses their suitability for research on partial left ventriculectomy.
Key words:
Animal model - Partial left ventriculectomy
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1 This work was supported by the Deutsche Stiftung für Herzforschung, Frankfurt, Germany
Dr. med. Stefan Christiansen
Klinik und Poliklinik für Thorax-, Herz- und Gefäßchirurgie
Westfälische Wilhelms-Universität Münster
Universität Münster
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Germany
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