Does a Suitable Animal Model for Research on Partial Left Ventriculectomy Exist?

S. Christiansen; U. R. Jahn; J. Stypmann; K. Redmann; H. H. Scheld; D. Hammel

doi:10.1055/s-2001-17795

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000085.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Thorac Cardiovasc Surg 2001; 49(5): 259-267
DOI: 10.1055/s-2001-17795

Editorial

Does a Suitable Animal Model for Research on Partial Left Ventriculectomy Exist?

Animal Models for PLV[1] S. Christiansen¹ , U. R. Jahn² , J. Stypmann³ , K. Redmann⁴ , H. H. Scheld¹ , D. Hammel¹

¹Klinik und Poliklinik fur Thorax-, Herz- und Gefäßchirurgie
²Klinik für Anästhesiologie und operative Intensivmedizin
³Klinik und Poliklinik für Kardiologie und Angiologie
⁴Experimentelle Thorax-, Herz- und Gefäßchirurgie
Westfälische Wilhelms-Universität, Münster, Germany

Further Information

Publication History

Publication Date:
15 October 2001 (online)

Abstract
Full Text
References

Buy Article Permissions and Reprints All articles of this category

Partial left ventriculectomy is a new surgical option quickly introduced into clinical use worldwide for treating end-stage heart failure in patients with dilated cardiomyopathy. Due to the overwhelming success of this new kind of surgical treatment for dilated cardiomyopathy, experimental research on the physiological and pathophysiological basis was initially not performed. Now, demands for an appropriate animal model have arisen more and more since the outcome of patients treated by partial left ventriculectomy has differed considerably. This review summarizes available experimental models for heart failure in large animals, and discusses their suitability for research on partial left ventriculectomy.

Key words:

Animal model - Partial left ventriculectomy

1 This work was supported by the Deutsche Stiftung für Herzforschung, Frankfurt, Germany

References

1 Batista R JV, Santos J LV, Takeshita N, Bocchmo L, Lima P N, Cunha M A. Partial Left Ventriculectomy to improve Left Ventricular Function in End-Stage Heart Disease. J Card Surg. 1996; 11 96-97

PubMed Search in Google Scholar
2 Angelini G D. Left Ventricular Volume Reduction For End Stage Heart Failure: Preliminary Clinical Results And Proposal Of An International Multicenter Registry And Prospective Study. Surgical Options For End-Stage Heart Failure. 1996 117

Search in Google Scholar
3 Angelini G D, Pryn S, Mehta D. et al . Left-ventricular-volume reduction for end-stage heart failure. Lancet. 1997; 350 489

Crossref PubMed Search in Google Scholar
4 Batista R. Partial left ventriculectomy - the Batista procedure. Eur J Cardiothorac Surg. 1999; 15 (Suppl 1) S12-S19

Crossref PubMed Search in Google Scholar
5 Batista R JV, Nery P, Bochino L. et al .Partial Left Ventriculectomy to Treat End-Stage Heart Disease. Abstracts of the 33rd Annual Meeting of The Society of Thoracic Surgeons 1997 60

Search in Google Scholar
6 Batista R JV, Verde J, Nery P. et al . Partial left ventriculectomy to treat end-stage heart disease. Ann Thorac Surg. 1997; 64 634-638

Crossref PubMed Search in Google Scholar
7 Bestetti R B, Bombonato R. Brasil JC. Partial ventriculectomy - a promising treatment for patients with end-stage congestive heart failure. Circulation. 1997; 96 3816

PubMed Search in Google Scholar
8 Bridges C R. The Batista procedure for dilated cardiomyopathy - an analysis that goes beyond “hand waving”. J Thorac Cardiovasc Surg. 1998; 116 369-371

PubMed Search in Google Scholar
9 Bryan A J, Angelini G D. Left ventricular volume reduction for end-stage heart failure: new horizon or false dawn?. Br J Hosp Med. 1997; 57 323-325

PubMed Search in Google Scholar
10 Carpentier A. Does surgical reduction of heart size reduce heart failure?. Lancet. 1997; 350 456

Crossref PubMed Search in Google Scholar
11 Chanda J, Kuribayashi R, Abe T. Ventricular remodelling in dilated cardiomyopathy. Lancet. 1997 ; 350 1705-1706

Crossref PubMed Search in Google Scholar
12 Chanda J, Kuribayashi R, Abe T. Batista operation for dilated cardiomyopathy - a physiologic concept. J Thorac Cardiovasc Surg. 1998; 115 261-262

PubMed Search in Google Scholar
13 Fukamachi K, McCarthy P M, Starling R C, Young J B. Effects of partial left ventriculectomy on cardiac performance. Circulation. 1998; 98 2101-2102

PubMed Search in Google Scholar
14 Konertz W, Khoynezhad A, Sidiropoulos A, Borak V, Baumann G. Early and intermediate results of left ventricular reduction surgery. Eur J Cardiothorac Surg. 1999; 15 (Suppl 1) S26-S30

Crossref PubMed Search in Google Scholar
15 McCarthy P M. Ventricular remodeling: hype or hope. Nature Med. 1996; 2 859-860

PubMed Search in Google Scholar
16 Replogle R L, Kaiser G C, Cohn L H. et al . Left ventricular reduction surgery (Society position paper). Ann Thorac Surg. 1997; 63 909-910

PubMed Search in Google Scholar
17 Dickstein M L, Spotnitz H M, Rose E A, Burkhoff D. Heart Reduction Surgery: An Analysis Of The Impact On Cardiac Function. J Thorac Cardiovasc Surg. 1997; 113 1032-1040

PubMed Search in Google Scholar
18 Ratcliffe M B, Hong J, Salahieh A, Ruch S, Wallace A W. The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: a simple finite element analysis. J Thorac Cardiovasc Surg. 1998; 116 566-577

Crossref PubMed Search in Google Scholar
19 Spotnitz H M. Macro Design, structure, and mechanics of the left ventricle. J Thorac Cardiovasc Surg. 2000; 119 1053-1077

PubMed Search in Google Scholar
20 Smith H J, Nuttall A. Experimental models of heart failure. Cardiovasc Res. 1985; 19 181-186

PubMed Search in Google Scholar
21 Iannini J P, Spinale F G. The Identification of Contributory Mechanisms for the Development and Progression of Congestive Heart Failure in Animal Models. J Heart Lung Transplant. 1996; 15 1138-1150

PubMed Search in Google Scholar
22 lyengar S RK, Charrett E JP, Iyengar C KS, Lynn R B. An experimental model with left ventricular hypertrophy caused by subcoronary aortic stenosis in dogs. J Thorac Cardiovasc Surg. 1973; 66 371-379

PubMed Search in Google Scholar
23 Carabello B A, Mee R, Collins J J, Kloner R A, Levin D, Grossman W. Contractile function in chronic gradually developing subcoronary aortic stenosis. Am J Physiol. 1981; 240 H80-H86

PubMed Search in Google Scholar
24 Kleinman L H, Wechsler A S, Rembert J C, Fedor J M, Greenfield J C. A reproducible model of moderate to severe concentric left ventricular hypertrophy. Am J Physiol. 1978; 234 H515-H519

PubMed Search in Google Scholar
25 O'Keefe D D, Hoffman J IE, Cheitlin R, O'Neill M J, Allard J R, Shapkin E. Coronary blood flow in experimental canine left ventricular hypertrophy. Circ Res. 1978; 43 43-51

PubMed Search in Google Scholar
26 Copeland J G, Maron B J, Luka N L, Ferrans V J, Michaelis L L. Experimental production of aortic valvular stenosis. J Thorac Cardiovasc Surg. 1974; 67 371-379

PubMed Search in Google Scholar
27 Allard J R, O'Neill M J, Hoffmann J IE. Valvar subcoronary aortic stenosis in dogs. Am J Physiol. 1979; 236 H780-H784

PubMed Search in Google Scholar
28 Weinberg E O, Schoen F J, George D. et al . Angiotensin-Converting Enzyme Inhibition Prolongs Survival and Modifies the Transition to Heart Failure in Rats With Pressure Overload Hypertrophy Due to Ascending Aortic Stenosis. Circulation. 1994; 90 1410-1422

Crossref PubMed Search in Google Scholar
29 Hufnagel C A, Roe B B, Barger A C. A technique for producing pulmonary artery stenosis. Surgery. 1951; 29 77-81

PubMed Search in Google Scholar
30 Welham K C, Silove E D, Wyse R K H. Experimental right ventricular hypertrophy and failure in swine. Cardiovasc Res. 1978; 12 61-65

PubMed Search in Google Scholar
31 Rastelli G C, Hallermann F J, Fellows J L, Swan H J C. Cardiac performance during exercise in dogs with constricted pulmonary artery. Circ Res. 1963; 13 410-419

PubMed Search in Google Scholar
32 McCanon D M, Krol B, Bruce D W. A clamp for precisely controlled progressive constriction of the pulmonary artery. J Appl Physiol. 1967; 22 171-173

PubMed Search in Google Scholar
33 Laks M M, Morady F, Garner D, Swan H J C. Relation of ventricular volume, compliance, and mass in the normal and pulmonary arterial banded canine heart. Cardiovasc Res. 1972; 6 187-198

PubMed Search in Google Scholar
34 Ferrario C M. Contribution of cardiac output and peripheral resistance to experimental renal hypertension. Am J Physiol. 1974; 226 711-717

PubMed Search in Google Scholar
35 Ferrario C M, Blumle C, Nadzam G R, McCubbin J W. An externally adjustable renal artery clamp. J Appl Physiol. 1971; 31 635-637

PubMed Search in Google Scholar
36 Ferrario C M, Page I H. Current views concerning cardiac output in the genesis of experimental hypertension. Circ Res. 1978; 43 821-831

PubMed Search in Google Scholar
37 Conway J, Hatton R. Development of deoxycorticosterone acetate hypertension in the dog. Circ Res. 1978; 43 I-82-I-86

PubMed Search in Google Scholar
38 Newman W H. A depressed response of left ventricular contractile force to isoproterenol and norepinephrine in dogs with congestive heart failure. Am Heart J. 1977; 93 216-221

PubMed Search in Google Scholar
39 Pinsky W W, Lewis R M, Hartley C J, Entman M L. Permanent changes of ventricular contractility and compliance in chronic volume overload. Am J Physiol. 1979; 237 H575-H583

PubMed Search in Google Scholar
40 Bolling S F, Deeb M, Brunsting L A, Bach D S. Early Outcome of mitral valve reconstruction in patients with end-stage cardiomyopathy. J Thorac Cardiovasc Surg. 1995; 109 676-683

PubMed Search in Google Scholar
41 Spring D A, Rowe G G. A device for production of aortic insufficiency in intact experimental animals. J Appl Physiol. 1970; 29 538-540

PubMed Search in Google Scholar
42 Alai J, Adam A, Ven F, Jamison W L. Production of aortic insufficiency with a study of arterial tracings. Surgery. 1954; 36 237-242

PubMed Search in Google Scholar
43 Feldman R L, Nichols W W, Thompson L V, Paley D M, Goldman R, Conti C R, Pepine C J. Left ventricular changes resulting from chronic aortic regurgitation in dogs. Am J Cardiol. 1984; 54 890-892

PubMed Search in Google Scholar
44 Moscovitz H L, Wilder R J. The pressure events of the cardiac cycle in the dog aortic valve lesions. Am Heart J. 1957; 54 572-579

Crossref PubMed Search in Google Scholar
45 Reimold S C, Byrne J G, Caguioa E S, Lee C C, Laurence R G, Peigh P S, Cohn L H, Lee R T. Load dependence of the effective regurgitant orifice area in a sheep model of aortic regurgitation. JACC. 1991; 18 1085-1090

PubMed Search in Google Scholar
46 Shiota T, Jones M, Delabays A, Li X, Yamada I, Ishii M, Acar P, Holcomb S, Pandian N G, Sahn D J. Direct Measurement of three-dimensionally reconstructed flow convergence surface area and regurgitant flow in aortic regurgitation. Circulation. 1997; 96 3687-3695

PubMed Search in Google Scholar
47 Slordahl S A, Piene H. Haemodynamic effects of arterial compliance, total peripheral resistance, and glyceryl trinitrate on regurgitant volume in aortic regurgitation. Cardiovasc Res. 1991; 25 869-874

PubMed Search in Google Scholar
48 Leshin S J, Horwitz L D. A closed-chest catheter technique for producing aortic regurgitation in dogs. J Appl Physiol. 1972; 33 693-695

PubMed Search in Google Scholar
49 Spinale F G, Ishihra K, Zile M, DeFryte G, Crawford F A, Carabello B A. Structural basis for changes in left ventricular function and geometry because of chronic mitral regurgitation and after correction of volume overload. J Thorac Cardiovasc Surg. 1993; 106 1147-1157

PubMed Search in Google Scholar
50 Barger A C, Roe B B, Richardson G S. Relation of valvular lesions of exercise to auricular pressure, work tolerance, and to development of chronic, congestive failure in dogs. Am J Physiol. 1952; 169 384-399

PubMed Search in Google Scholar
51 Mertes H, Segar D S, Johnson M, Ryan T. Sawada SG, Feigenbaum H. Assessment of Hibernating Myocardium by Dobutamine Stimulation in a Canine Model. JACC. 1995; 261 348-1355

PubMed Search in Google Scholar
52 Kramer C M, Lima J AC, Reichek N, Ferrari V A, Llaneras M R, Palmon L C, Yeh I T, Tallant B, Axel L. Regional differences in function within noninfarcted myocardium during left ventricular remodeling. Circulation. 1993; 88 1279-1288

PubMed Search in Google Scholar
53 Bolukoglu H, Liedtke J, Nellis S H, Eggleston A M, Subramanian R, Renstrom B. An animal model of chronic coronary stenosis resulting in hibernating myocardium. Am J Physiol. 1992; 263 H20-H29

PubMed Search in Google Scholar
54 David M S, Charrette E JP, Lynn R B. Experimental coronary artery thrombosis for production of cardiogenic shock. Can J Surg. 1970; 13 189-195

PubMed Search in Google Scholar
55 Salazar A E. Experimental myocardial infarction. Induction of Coronary Thrombosis in the Intact Closed-Chest Dog. Circ Res. 1961; 9 1351-1356

PubMed Search in Google Scholar
56 Kordenat R K, Kesdi P, Stanley E L. A new catheter technique for producing experimental coronary thrombosis and selective coronary visualization. Am Heart J. 1972; 83 360-364

Crossref PubMed Search in Google Scholar
57 Lluch S, Moguilevsku H C, Pietra G, Shaffer A B, Hirsch L J, Fishman A P. A reproducible model of cardiogenic shock in the dog. Circulation. 1969; 39 205-218

PubMed Search in Google Scholar
58 Guzman S V, Swenson E, Mitchell R. Mechanism of cardiogenic shock. Circ Res. 1962; 10 746-752

PubMed Search in Google Scholar
59 Szamosi A. Experimental occlusion of the coronary arteries in the closed-chest dog - a selective method. Acta Radiol Diagn. 1972; 12 545-553

PubMed Search in Google Scholar
60 Hammer J, Pisa Z. A method of isolated gradual occlusion of a main branch of a coronary artery in closed-chest dogs. Am Heart J. 1962; 64 67-70

Crossref PubMed Search in Google Scholar
61 Cohen M V, Eldh P. Experimental myocardial infarction in the closed-chest dog: controlled production of large or small areas of necrosis. Am Heart J. 1973; 86 798-804

Crossref PubMed Search in Google Scholar
62 Gensini G G, Palacio A, Buonanno C. Kelly AE, Muller WF. Superselective coronary- occlusion under cinefluorographic control in experimental animals: technique and results. Circulation. 1966; 34 III108-III109

PubMed Search in Google Scholar
63 Ribeilima J. Selective embolisation of the coronary arteries. A hemodynamic, metabolic and radiologic study. Proc Soc Exp Biol Med. 1964; 117 367-369

PubMed Search in Google Scholar
64 Khomaziuk A I, Nescheret A P, Kuzminskii N P. Some new ways of experimental research in myocardial infarction. Kardiologia. 1965; 5 19-23

PubMed Search in Google Scholar
65 Sabbah H N, Stein P D, Kono T. et al . A canine model of chronic heart failure produced by multiple sequential coronary microembolizations. Am J Physiol. 1991; 260 H1379-H1384

PubMed Search in Google Scholar
66 Goldstein S, Sabbah H N. Chronic Heart Failure in Dogs Created by Multiple Sequential Intracoronary Microembolizations. Heart Failure. 1995; 11 196-206

PubMed Search in Google Scholar
67 Weber K T, Malinin T I, Dennison B H, Faqua J M, Speaker D M, Hastings F W. Experimental myocardial ischemia and infarction. Am J Cardiol. 1972; 29 793-802

Crossref PubMed Search in Google Scholar
68 Nakhjavan F K, Shedrovilzky H, Goldberg H. Experimental myocardial infarction in dogs: description of a closed chest technique. Circulation. 1968; 38 777-782

PubMed Search in Google Scholar
69 Johnsrude I S, Goodrich J K. An experimental partial occlusive device for vessels delivered by arterial catheter. Am Heart J. 1969; 77 805-808

Crossref PubMed Search in Google Scholar
70 Nuttall A, Smith H J, Loveday B E. A clinically relevant model of heart failure: effects of ticlopidine. Cardiovasc Res. 1985; 12 187-192

PubMed Search in Google Scholar
71 van Vleet J F, Greenwood L A, Ferrans V J. Pathologic Features of Adriamycin Toxicosis in young pigs: Nonskeletal Lesions. Am J Vet Res. 1979; 40 1537-1552

PubMed Search in Google Scholar
72 Magovern J A, Christlieb I Y, Badylak S F, Lantz G C, Kao R L. A Model of Left Ventricular Dysfunction Caused by Intracoronary Adriamycin. Ann Thorac Surg. 1992; 53 861-863

PubMed Search in Google Scholar
73 Shah H R, Vaynblat M, Ramdev G, Cunningham J N, Chiavarelli M. Experimental cardiomyopathy as a model of chronic heart failure. J Invest Surg. 1997 ; 10 387-396

PubMed Search in Google Scholar
74 Toyoda Y, Okada M, Kashem M A. A canine model of dilated cardiomyopathy induced by a repetitive intracoronary doxorubicin administration. J Thorac Cardiovasc Surg. 1998; 115 1367-1373

PubMed Search in Google Scholar
75 Jaenke R S. Delayed and progressive myocardial lesions after adriamycin administration in the rabbit. Cancer Res. 1976; 36 2958-2966

PubMed Search in Google Scholar
76 Fajardo L F, Stewart J R. Experimental radiation induced heart disease. I. Light microscopic studies. Am J Pathol. 1970; 59 299-316

PubMed Search in Google Scholar
77 Fajardo L F, Stewart J R. Pathogenesis of Radiation-Induced Myocardial Fibrosis. Lab Invest. 1973; 29 244-257

PubMed Search in Google Scholar
78 Fajardo L F, Stewart J R, Cohn K E. Morphology of Radiation-Induced Heart Disease. Arch Path. 1968; 86 512-519

PubMed Search in Google Scholar
79 Gillette E L, McChesney S L, Hoopes P J. Isoeffect curves for radiation induced cardiomyopathy in the dog. Int J Radiat Oncol Biol Phys. 1985; 11 2091-2097

PubMed Search in Google Scholar
80 Gillette S M. Gillette EL, Shida T, Boon J, Miller CW, Powers BE. Late radiation response of canine mediastinal tissues. Radiother Oncol. 1992; 23 41-52

PubMed Search in Google Scholar
81 Carlyle P F, Cohn J N. A nonsurgical canine model of chronic left ventricular myocardial dysfunction. Am J Physiol. 1983; 244 H769-H774

PubMed Search in Google Scholar
82 Hendrick D A, Smith A C, Kratz J M, Crawford F A, Spinale F G. The pig as a model of tachycardia and dilated cardiomyopathy. Lab Anim Sci. 1990; 40 495-501

PubMed Search in Google Scholar
83 Vatner D E, Sato N, Kiuchi K, Shannon R P, Vatner S F. Decrease in Myocardial Ryanodine Receptors and Altered Excitation-Contraction Coupling Early in the Development of Heart Failure. Circulation. 1994; 90 1423-1430

PubMed Search in Google Scholar
84 Shannon R P. The relationship between altered load and impaired diastolic function in conscious dogs with pacing induced heart failure. Adv Exp Med Biol. 1993; 346 337-345

PubMed Search in Google Scholar
85 Shannon R P, Komamura K, Shen Y -T, Bishop S P, Vatner S F. Impaired regional subendocardial coronary flow reserve in conscious dogs with pacing-induced heart failure. Am J Physiol. 1993; 265 H801-809

PubMed Search in Google Scholar
86 Komamura K, Shannon R P, Ihara T. et al . Exhaustion of Frank-Starling mechanism in conscious dogs with heart failure. Am J Physiol. 1993; 265 H 1119-1131

PubMed Search in Google Scholar
87 Patel H J, Pilla J J, Pohdon D J. et al . Ten weeks of rapid ventricular pacing creates a long-term model of left ventricular dysfunction. J Thorac Cardiovasc Surg. 2000; 119 834-841

PubMed Search in Google Scholar
88 Laks M M, Morady F, Swan H JC. Myocardial hypertrophy produced by chronic infusion of subhypertensive doses of norepinephrine in the dog. Chest. 1973 ; 64 75-78

PubMed Search in Google Scholar
89 Maggs P R, Nener T PE, Ellis F H. Effect of left ventricular akinesis on cardiac performance: experimental study using a new model. Circulation. 1979; 59 1019-1024

PubMed Search in Google Scholar
90 Baretti R, Mizuno A, Buckberg G D, Child J S. Batista procedure: elliptical modeling against spherical distension. Eur J Cardiothorac Surg. 2000 ; 17 52-57

Crossref PubMed Search in Google Scholar
91 Batista R JV. Partial ventriculectomy for diameter heart surgery. BAM. 1997; 7 57-60

PubMed Search in Google Scholar
92 Starr I, Jeffers W A, Meade R H. The absence of conspicuous increments of venous pressure after severe damage to the right ventricle of the dog, with a discussion of the relation between clinical congestive failure and heart disease. Am Heart J. 1943; 26 291-301

Crossref PubMed Search in Google Scholar

1 This work was supported by the Deutsche Stiftung für Herzforschung, Frankfurt, Germany

Dr. med. Stefan Christiansen

Klinik und Poliklinik für Thorax-, Herz- und Gefäßchirurgie
Westfälische Wilhelms-Universität Münster
Universität Münster

Albert-Schweitzer-Straße 33

48149 Münster

Germany

Phone: (+49) (251) 834-74 01

Fax: (+49) (251) 834-83 16