Synlett 2001; 2001(11): 1781-1783
DOI: 10.1055/s-2001-18075
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InCl3-SiO2 Catalyzed Electrophilic Amination of Arenes: A Facile and Rapid Synthesis of Aryl Hydrazides

J. S. Yadav* , B. V. Subba Reddy, G. Mahesh Kumar, C. Madan
  • *Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India; Fax + 91(40)7 17 05 12; E-mail: yadav@iict.ap.nic.in
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Publication History

Publication Date:
29 October 2001 (online)

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Electron-rich arenes undergo electrophilic amination with diethyl azodicarboxylate on the surface of silica gel impregnated with indium trichloride in solvent-free conditions to afford para-substituted aryl hydrazides. Improved yields and enhanced rates are obtained by employing microwave irradiation.

InCl3-SiO2 - arenes - aryl hydrazides - microwaves