Download PDF
Synlett 2001; 2001(12): 1841-1842
DOI: 10.1055/s-2001-18763
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

N-(1′-Benzotriazolylmethyl)-5-phenylmorpholin-2-one: A Stable Crystalline Chiral Azomethine Ylid Precursor

David J. Aldous* , Estelle M.-N. Hamelin, Laurence M. Harwood, Sukanthini Thurairatnam
  • *Rhône Poulenc Rorer Limited, Rainham Road South, Dagenham, Essex RM10 7XS, UK; Fax: + 44 (118) 9316782; E-mail: l.m.harwood@reading.ac.uk
Further Information

Publication History

Publication Date:
04 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

The crystalline adduct of (5S)-5-phenylmorpholin-2-one with formaldehyde and benzotriazole on treatment with acid generates an azomethine ylid which may be trapped with a range of dipolarophiles in yields superior to those using in situ generation methodology.

chiral - azomethine ylid - benzotriazole - dipolar cycloaddition