Planta Med 2002; 68(1): 86-87
DOI: 10.1055/s-2002-20058
Letter

© Georg Thieme Verlag Stuttgart · New York

Inhibition of HIV-1 Reverse Transcriptase and HIV-1 Replication by Calophyllum Coumarins and Xanthones

H. R.W. Dharmaratne1 , G. T. Tan2 , G. P.K. Marasinghe1 , J. M. Pezzuto2
  • 11 Natural Products Programme, Institute of Fundamental Studies, Kandy, Sri Lanka
  • 22 Programme for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Chicago, Illinois, U.S.A.
Weitere Informationen

Publikationsverlauf

January 19, 2001

July 7, 2001

Publikationsdatum:
31. Januar 2002 (online)

Abstract

As part of our continuing study on the Calophyllum species, a number of coumarins, xanthones and chromene acids from different Calophyllum species of Sri Lanka were tested for inhibitory activity against the HIV-1 and its virally-encoded reverse transcriptase (RT). These compounds were found to be inactive in both the HIV-1 RT and whole virus systems. In contrast, cordatolide A and B demonstrated IC50 values of 19.3 and 11.7 μM, respectively, against HIV-1 replication in a novel green fluorescent protein (GFP)-based reporter cell assay (HOG.R5).

References

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Dr. H. R. W. Dharmaratne

Natural Products Propgramme

Institute of Fundamental Studies

Kandy

Sri Lanka

eMail: hrwd13@hotmail.com

Fax: 94 - 8 232131